Tuesday, December 1, 2009

Subtype Diversity - post for 12/2 class

I found this article to be very interesting, especially the discussion of the possibilities for an HIV vaccine. I wish I knew more about how the immune system worked so that I could better follow some of the technicalities and nuance. Are there any areas in the world where there are many common subtypes? I would imagine that a place like this would be very valuable to study the relative fitness of the various types. Do certain types out-compete others? Although I guess it is far more complicated than simple competition, due to all the host/virus/environment factors involved. If it was clear that one type is more fit, would we know by now?

On that note, it seems that much more research is needed to fully understand subtype diversity - it is certainly needed for vaccine development! The fact that subtype does not seem to affect clinical progression is promising, but at the same time it seems that it would be ideal to reduce/contain the number of circulating subtypes, especially if we want treatments and vaccines to work as effectively as possible! I'd be curious to know if there are any efforts underway currently to find and contain emerging subtypes. Would this be a valid use of resources, I wonder?

Another question I am very curious about - how were the vaccines tested ethically? The way the author wrote, "In two large, phase 3 trials of a monomeric
form of the external glycoprotein 120, conducted in the United States and Thailand, the protein failed to protect healthy subjects from HIV infection" almost implied that healthy people were infected!

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